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There are several depending on where you want to stay in the city. The largest concentrations of hotels are downtown, south of downtown by the airport next to I-65 & I-264, and east of downtown by I-64 off of Hurstbourne Pkwy. & Blankenbaker Ln.
If you search on Google for Louisville & hotel, it will show ratings given on citysearch, mobiltravelguide, travelocity, and tripadvisor.
I stayted at the Hampton there. It was nice and clean. There are tons of nice hotels downtown. The Gattes hOuse or something like that looks to be the coolest!